Drug interactions
Cyclizine + Nortriptyline
Severity: Moderate
Cyclizine and Nortriptyline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are anticholinergic and sedating, so combined use can cause drowsiness, dry mouth, constipation, urinary retention, tachycardia and confusion. Older patients and those with glaucoma or prostatic disease are at greater risk.
What this interaction means in plain words
Cyclizine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Nortriptyline belongs to Central Nervous System.
Why it happens
Additive muscarinic and histamine H1 receptor antagonism.
What to do
Monitor for anticholinergic toxicity and sedation, and counsel against driving. Consider a less anticholinergic antiemetic in older adults.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Nortriptyline?
MediHelp rates the interaction as moderate. Cyclizine and Nortriptyline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are anticholinergic and sedating, so combined use can cause drowsiness, dry mouth, constipation, urinary retention, tachycardia and confusion. Older patients and those with glaucoma or prostatic disease are at greater risk.
How serious is the interaction between Cyclizine and Nortriptyline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and counsel against driving. Consider a less anticholinergic antiemetic in older adults.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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