Drug interactions
Cyclizine + Primidone
Severity: Moderate
Cyclizine and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized partly to phenobarbital and has sedative effects, and cyclizine is a sedating antihistamine. Together they can cause excess drowsiness, impaired coordination and CNS depression.
What this interaction means in plain words
Cyclizine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression through barbiturate-type GABA-A potentiation and histamine H1 blockade.
What to do
Monitor for oversedation and warn against driving and alcohol. Reduce doses if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Cyclizine with Primidone?
MediHelp rates the interaction as moderate. Cyclizine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized partly to phenobarbital and has sedative effects, and cyclizine is a sedating antihistamine. Together they can cause excess drowsiness, impaired coordination and CNS depression.
How serious is the interaction between Cyclizine and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and warn against driving and alcohol. Reduce doses if drowsiness is troublesome.
What other medicines interact with Cyclizine?
MediHelp also lists interactions of Cyclizine with, for example, Calcium / magnesium / potassium / sodium oxybates, Henbane, Sodium oxybate. The full list is on the Cyclizine page.
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