Drug interactions
Cyclizine + Scopolamine
Severity: Moderate
Cyclizine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine is an antihistamine with anticholinergic properties and also causes drowsiness. With scopolamine, antimuscarinic and sedative effects are additive, which may cause dry mouth, blurred vision, confusion and urinary retention.
What this interaction means in plain words
Cyclizine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism and central sedation.
What to do
Avoid using both as antiemetics together unless clearly needed, and monitor for confusion, sedation and urinary retention, particularly in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Scopolamine?
MediHelp rates the interaction as moderate. Cyclizine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine is an antihistamine with anticholinergic properties and also causes drowsiness. With scopolamine, antimuscarinic and sedative effects are additive, which may cause dry mouth, blurred vision, confusion and urinary retention.
How serious is the interaction between Cyclizine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both as antiemetics together unless clearly needed, and monitor for confusion, sedation and urinary retention, particularly in older patients.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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