Drug interactions
Cyclizine + Trospium
Severity: Moderate
Cyclizine and Trospium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclizine has antimuscarinic properties, so using it with trospium can add to anticholinergic effects including dry mouth, constipation, blurred vision and urinary retention. Older patients may develop confusion.
What this interaction means in plain words
Cyclizine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclizine belongs to Respiratory; Trospium belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic symptoms and limit duration of cyclizine. Consider a non-anticholinergic antiemetic if symptoms develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclizine and Trospium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Trospium
- Clozapine + Trospium Major
- Pramlintide + Trospium Major
- Thioridazine + Trospium Major
- Trihexyphenidyl + Trospium Major
- Aclidinium + Trospium Moderate
- Amantadine + Trospium Moderate
Other interactions of Cyclizine
- Calcium / magnesium / potassium / sodium oxybates + Cyclizine Major
- Cyclizine + Henbane Major
- Cyclizine + Sodium oxybate Major
- Abobotulinumtoxina + Cyclizine Moderate
- Alfentanil + Cyclizine Moderate
- Alprazolam + Cyclizine Moderate
Frequently asked questions
Can I take Cyclizine with Trospium?
MediHelp rates the interaction as moderate. Cyclizine and Trospium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclizine has antimuscarinic properties, so using it with trospium can add to anticholinergic effects including dry mouth, constipation, blurred vision and urinary retention. Older patients may develop confusion.
How serious is the interaction between Cyclizine and Trospium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic symptoms and limit duration of cyclizine. Consider a non-anticholinergic antiemetic if symptoms develop.
What other medicines interact with Trospium?
MediHelp also lists interactions of Trospium with, for example, Clozapine, Pramlintide, Thioridazine. The full list is on the Trospium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
