Drug interactions
Cyclobenzaprine + Flavoxate
Severity: Moderate
Cyclobenzaprine and Flavoxate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and has anticholinergic effects. With flavoxate it may cause additive dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Cyclobenzaprine and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Flavoxate belongs to Genitourinary.
Why it happens
Additive antimuscarinic pharmacodynamic effects.
What to do
Monitor for anticholinergic effects and urinary retention, particularly in older adults. Limit the duration of cyclobenzaprine and lower the dose if symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flavoxate
- Clozapine + Flavoxate Major
- Abobotulinumtoxina + Flavoxate Moderate
- Aclidinium + Flavoxate Moderate
- Amantadine + Flavoxate Moderate
- Amitriptyline + Flavoxate Moderate
- Amoxapine + Flavoxate Moderate
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Flavoxate?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Flavoxate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and has anticholinergic effects. With flavoxate it may cause additive dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Cyclobenzaprine and Flavoxate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and urinary retention, particularly in older adults. Limit the duration of cyclobenzaprine and lower the dose if symptoms appear.
What other medicines interact with Flavoxate?
MediHelp also lists interactions of Flavoxate with, for example, Clozapine, Abobotulinumtoxina, Aclidinium. The full list is on the Flavoxate page.
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