Drug interactions
Cyclobenzaprine + Hydrocodone
Severity: Moderate
Cyclobenzaprine and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is a sedating tricyclic-related muscle relaxant that adds to the CNS depression of hydrocodone. It also has anticholinergic and weak serotonergic effects, increasing drowsiness and confusion, especially in older adults.
What this interaction means in plain words
Cyclobenzaprine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression from opioid agonism and sedating antihistaminic and anticholinergic effects of cyclobenzaprine.
What to do
Use the lowest effective doses for the shortest time and monitor for sedation and respiratory depression. Avoid in older adults where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Hydrocodone?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is a sedating tricyclic-related muscle relaxant that adds to the CNS depression of hydrocodone. It also has anticholinergic and weak serotonergic effects, increasing drowsiness and confusion, especially in older adults.
How serious is the interaction between Cyclobenzaprine and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and monitor for sedation and respiratory depression. Avoid in older adults where possible.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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