Drug interactions
Cyclobenzaprine + Levetiracetam
Severity: Minor
Cyclobenzaprine and Levetiracetam: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence, dizziness and impaired coordination, which may be additive. Fall risk and reduced alertness may increase, especially at treatment start.
What this interaction means in plain words
Cyclobenzaprine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclobenzaprine belongs to Musculoskeletal; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects; no pharmacokinetic interaction is expected.
What to do
Counsel patients about drowsiness and driving, and reduce cyclobenzaprine dose if excess sedation occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Levetiracetam
Frequently asked questions
Can I take Cyclobenzaprine with Levetiracetam?
MediHelp rates the interaction as minor. Cyclobenzaprine and Levetiracetam have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs can cause somnolence, dizziness and impaired coordination, which may be additive. Fall risk and reduced alertness may increase, especially at treatment start.
How serious is the interaction between Cyclobenzaprine and Levetiracetam?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about drowsiness and driving, and reduce cyclobenzaprine dose if excess sedation occurs.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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