Drug interactions
Cyclobenzaprine + Loxapine
Severity: Moderate
Cyclobenzaprine and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation and anticholinergic effects, so combined use raises the risk of drowsiness, confusion and constipation. Loxapine's effect on cardiac conduction may be compounded by cyclobenzaprine.
What this interaction means in plain words
Cyclobenzaprine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Loxapine belongs to Central Nervous System.
Why it happens
Additive CNS depressant and anticholinergic effects.
What to do
Monitor for oversedation and anticholinergic toxicity, and lower doses if these develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Cyclobenzaprine with Loxapine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation and anticholinergic effects, so combined use raises the risk of drowsiness, confusion and constipation. Loxapine's effect on cardiac conduction may be compounded by cyclobenzaprine.
How serious is the interaction between Cyclobenzaprine and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and anticholinergic toxicity, and lower doses if these develop.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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