Drug interactions
Cyclobenzaprine + Methocarbamol
Severity: Moderate
Cyclobenzaprine and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
These two centrally acting muscle relaxants have additive sedative effects, increasing drowsiness, dizziness and impaired coordination. Combining them offers no established therapeutic advantage.
What this interaction means in plain words
Cyclobenzaprine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive CNS depression.
What to do
Avoid concurrent use of both muscle relaxants; if combined briefly, monitor for sedation and counsel on driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Methocarbamol
Frequently asked questions
Can I take Cyclobenzaprine with Methocarbamol?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. These two centrally acting muscle relaxants have additive sedative effects, increasing drowsiness, dizziness and impaired coordination. Combining them offers no established therapeutic advantage.
How serious is the interaction between Cyclobenzaprine and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of both muscle relaxants; if combined briefly, monitor for sedation and counsel on driving.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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