Drug interactions
Cyclobenzaprine + Methohexital
Severity: Moderate
Cyclobenzaprine and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methohexital is a barbiturate anesthetic that causes marked CNS and respiratory depression, and cyclobenzaprine adds sedation. This may deepen sedation and prolong recovery.
What this interaction means in plain words
Cyclobenzaprine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depression from pharmacodynamic synergy.
What to do
Inform the anesthesia team about cyclobenzaprine use. Titrate methohexital carefully and monitor sedation, ventilation and oxygenation through recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Methohexital
Frequently asked questions
Can I take Cyclobenzaprine with Methohexital?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methohexital is a barbiturate anesthetic that causes marked CNS and respiratory depression, and cyclobenzaprine adds sedation. This may deepen sedation and prolong recovery.
How serious is the interaction between Cyclobenzaprine and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about cyclobenzaprine use. Titrate methohexital carefully and monitor sedation, ventilation and oxygenation through recovery.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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