Drug interactions
Cyclobenzaprine + Orphenadrin
Severity: Moderate
Cyclobenzaprine and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating and anticholinergic, as is orphenadrine. Using both increases the risk of oversedation, confusion and anticholinergic toxicity without clear added benefit.
What this interaction means in plain words
Cyclobenzaprine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive antimuscarinic and central sedative effects.
What to do
Avoid using two muscle relaxants together. If unavoidable, use low doses and monitor for sedation and anticholinergic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Orphenadrin?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclobenzaprine is structurally related to tricyclic antidepressants and is sedating and anticholinergic, as is orphenadrine. Using both increases the risk of oversedation, confusion and anticholinergic toxicity without clear added benefit.
How serious is the interaction between Cyclobenzaprine and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two muscle relaxants together. If unavoidable, use low doses and monitor for sedation and anticholinergic symptoms.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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