Drug interactions
Cyclobenzaprine + Pilocarpine
Severity: Minor
Cyclobenzaprine and Pilocarpine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist and cyclobenzaprine has anticholinergic effects, so they may oppose one another. Reduced pilocarpine effect on salivation is possible, but clinical significance is uncertain.
What this interaction means in plain words
Cyclobenzaprine and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclobenzaprine belongs to Musculoskeletal; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor whether pilocarpine still relieves dry mouth. Adjust the dose or consider an alternative muscle relaxant if efficacy is lost.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Cyclobenzaprine with Pilocarpine?
MediHelp rates the interaction as minor. Cyclobenzaprine and Pilocarpine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pilocarpine is a muscarinic agonist and cyclobenzaprine has anticholinergic effects, so they may oppose one another. Reduced pilocarpine effect on salivation is possible, but clinical significance is uncertain.
How serious is the interaction between Cyclobenzaprine and Pilocarpine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor whether pilocarpine still relieves dry mouth. Adjust the dose or consider an alternative muscle relaxant if efficacy is lost.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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