Drug interactions
Cyclobenzaprine + Quetiapine
Severity: Moderate
Cyclobenzaprine and Quetiapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sedating and anticholinergic and each can prolong the QT interval, so combined use increases drowsiness, orthostasis, anticholinergic effects and arrhythmia risk. The risk is highest with other QT-prolonging drugs, electrolyte disturbance or cardiac disease.
What this interaction means in plain words
Cyclobenzaprine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Quetiapine belongs to Central Nervous System.
Why it happens
Additive CNS depression, anticholinergic effects and QT prolongation.
What to do
Use the lowest effective doses and monitor sedation and anticholinergic effects. Check an ECG and electrolytes in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Frequently asked questions
Can I take Cyclobenzaprine with Quetiapine?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Quetiapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sedating and anticholinergic and each can prolong the QT interval, so combined use increases drowsiness, orthostasis, anticholinergic effects and arrhythmia risk. The risk is highest with other QT-prolonging drugs, electrolyte disturbance or cardiac disease.
How serious is the interaction between Cyclobenzaprine and Quetiapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and anticholinergic effects. Check an ECG and electrolytes in patients with QT risk factors.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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