Drug interactions
Cyclobenzaprine + Secobarbital
Severity: Moderate
Cyclobenzaprine and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates strongly depress the CNS, and cyclobenzaprine adds sedation, which may cause profound drowsiness, impaired respiration and falls. Barbiturate enzyme induction may also lower cyclobenzaprine exposure.
What this interaction means in plain words
Cyclobenzaprine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression, with possible enzyme induction by secobarbital.
What to do
Avoid the combination in patients with respiratory compromise and use the lowest effective doses. Counsel against alcohol, driving and other sedatives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Secobarbital?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates strongly depress the CNS, and cyclobenzaprine adds sedation, which may cause profound drowsiness, impaired respiration and falls. Barbiturate enzyme induction may also lower cyclobenzaprine exposure.
How serious is the interaction between Cyclobenzaprine and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in patients with respiratory compromise and use the lowest effective doses. Counsel against alcohol, driving and other sedatives.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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