Drug interactions
Cyclobenzaprine + Sumatriptan
Severity: Moderate
Cyclobenzaprine and Sumatriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have serotonergic activity, so using them together may increase the chance of serotonin syndrome. The risk is probably low with occasional triptan use, but the effect can be serious if it occurs.
What this interaction means in plain words
Cyclobenzaprine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Sumatriptan belongs to Central Nervous System.
Why it happens
Additive serotonergic effects (5-HT1B/1D agonism by sumatriptan plus serotonin reuptake inhibition and receptor activity by cyclobenzaprine).
What to do
Counsel the patient on symptoms of serotonin syndrome and use the lowest effective doses. Consider a non-serotonergic muscle relaxant if both are needed regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Sumatriptan
- Almotriptan + Sumatriptan Contraindicated
- Dihydroergotamine intranasal + Sumatriptan Contraindicated
- Dihydroergotamine + Sumatriptan Contraindicated
- Eletriptan + Sumatriptan Contraindicated
- Ergoloid mesylates + Sumatriptan Contraindicated
- Ergotamine + Sumatriptan Contraindicated
Frequently asked questions
Can I take Cyclobenzaprine with Sumatriptan?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Sumatriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have serotonergic activity, so using them together may increase the chance of serotonin syndrome. The risk is probably low with occasional triptan use, but the effect can be serious if it occurs.
How serious is the interaction between Cyclobenzaprine and Sumatriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on symptoms of serotonin syndrome and use the lowest effective doses. Consider a non-serotonergic muscle relaxant if both are needed regularly.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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