Drug interactions
Cyclobenzaprine + Verapamil
Severity: Moderate
Cyclobenzaprine and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is not serotonergic, so the legacy serotonin rationale is inaccurate. However, verapamil inhibits CYP3A4 and may modestly raise cyclobenzaprine exposure, increasing sedation, anticholinergic effects and QT risk; additive hypotension is possible.
What this interaction means in plain words
Cyclobenzaprine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclobenzaprine belongs to Musculoskeletal; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibition of CYP3A4 (a minor pathway for cyclobenzaprine) may increase cyclobenzaprine concentrations, with additive cardiovascular effects.
What to do
Monitor for excess sedation, anticholinergic effects, hypotension and bradycardia or conduction changes. Reduce the cyclobenzaprine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclobenzaprine
- Cyclobenzaprine + Isocarboxazid Contraindicated
- Cyclobenzaprine + Linezolid Contraindicated
- Cyclobenzaprine + Phenelzine Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Cyclobenzaprine + Selegiline Contraindicated
- Cyclobenzaprine + Selegiline transdermal Contraindicated
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Cyclobenzaprine with Verapamil?
MediHelp rates the interaction as moderate. Cyclobenzaprine and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil is not serotonergic, so the legacy serotonin rationale is inaccurate. However, verapamil inhibits CYP3A4 and may modestly raise cyclobenzaprine exposure, increasing sedation, anticholinergic effects and QT risk; additive hypotension is possible.
How serious is the interaction between Cyclobenzaprine and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation, anticholinergic effects, hypotension and bradycardia or conduction changes. Reduce the cyclobenzaprine dose if adverse effects appear.
What other medicines interact with Cyclobenzaprine?
MediHelp also lists interactions of Cyclobenzaprine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Cyclobenzaprine page.
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