Drug interactions
Cyclopenthiazide + Furosemide
Severity: Moderate
Cyclopenthiazide and Furosemide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Using a loop diuretic with a thiazide gives synergistic diuresis and can cause marked hypokalemia, hyponatremia, hypomagnesemia, dehydration and renal impairment.
What this interaction means in plain words
Cyclopenthiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Sequential nephron blockade producing additive natriuresis and kaliuresis.
What to do
Monitor electrolytes, renal function and weight after starting, and replace potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Furosemide
- Amifostine + Furosemide Major
- Amikacin + Furosemide Major
- Carbenoxolone + Furosemide Major
- Cephaloridine + Furosemide Major
- Cisplatin + Furosemide Major
- Digoxin + Furosemide Major
Frequently asked questions
Can I take Cyclopenthiazide with Furosemide?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Furosemide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Using a loop diuretic with a thiazide gives synergistic diuresis and can cause marked hypokalemia, hyponatremia, hypomagnesemia, dehydration and renal impairment.
How serious is the interaction between Cyclopenthiazide and Furosemide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function and weight after starting, and replace potassium and magnesium as needed.
What other medicines interact with Furosemide?
MediHelp also lists interactions of Furosemide with, for example, Amifostine, Amikacin, Carbenoxolone. The full list is on the Furosemide page.
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