Drug interactions
Cyclopenthiazide + Hydrochlorothiazide-lisinopril
Severity: Moderate
Cyclopenthiazide and Hydrochlorothiazide-lisinopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclopenthiazide is a thiazide diuretic, so adding it to a regimen that already contains hydrochlorothiazide duplicates therapy. This increases diuresis and the risk of hypokalemia, hyponatremia and volume depletion. The potassium-sparing effect of lisinopril only partly offsets this.
What this interaction means in plain words
Cyclopenthiazide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubular Na-Cl cotransporter, increasing urinary potassium and sodium loss.
What to do
Avoid combining two thiazides; use a single agent at an adjusted dose. If it is unavoidable, monitor serum potassium, sodium and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-lisinopril
- Dofetilide + Hydrochlorothiazide-lisinopril Contraindicated
- Hydrochlorothiazide-lisinopril + Sacubitril / valsartan Contraindicated
- Amifostine + Hydrochlorothiazide-lisinopril Major
- Amiloride + Hydrochlorothiazide-lisinopril Major
- Benazepril + Hydrochlorothiazide-lisinopril Major
- Bendroflumethiazide + Hydrochlorothiazide-lisinopril Major
Frequently asked questions
Can I take Cyclopenthiazide with Hydrochlorothiazide-lisinopril?
MediHelp rates the interaction as moderate. Cyclopenthiazide and Hydrochlorothiazide-lisinopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclopenthiazide is a thiazide diuretic, so adding it to a regimen that already contains hydrochlorothiazide duplicates therapy. This increases diuresis and the risk of hypokalemia, hyponatremia and volume depletion. The potassium-sparing effect of lisinopril only partly offsets this.
How serious is the interaction between Cyclopenthiazide and Hydrochlorothiazide-lisinopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining two thiazides; use a single agent at an adjusted dose. If it is unavoidable, monitor serum potassium, sodium and renal function.
What other medicines interact with Hydrochlorothiazide-lisinopril?
MediHelp also lists interactions of Hydrochlorothiazide-lisinopril with, for example, Dofetilide, Sacubitril / valsartan, Amifostine. The full list is on the Hydrochlorothiazide-lisinopril page.
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