Drug interactions
Cyclopenthiazide + Insulin glargine
Severity: Minor
Cyclopenthiazide and Insulin glargine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can impair glucose tolerance and raise blood glucose, which may reduce the effectiveness of insulin glargine. The effect is usually modest at low doses but can become relevant in some patients.
What this interaction means in plain words
Cyclopenthiazide and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Thiazides cause potassium depletion that reduces insulin secretion and may increase insulin resistance, opposing insulin action.
What to do
Check blood glucose after starting or increasing the thiazide and adjust the insulin glargine dose if control worsens. Correct hypokalemia if present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Insulin glargine
Frequently asked questions
Can I take Cyclopenthiazide with Insulin glargine?
MediHelp rates the interaction as minor. Cyclopenthiazide and Insulin glargine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics can impair glucose tolerance and raise blood glucose, which may reduce the effectiveness of insulin glargine. The effect is usually modest at low doses but can become relevant in some patients.
How serious is the interaction between Cyclopenthiazide and Insulin glargine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose after starting or increasing the thiazide and adjust the insulin glargine dose if control worsens. Correct hypokalemia if present.
What other medicines interact with Insulin glargine?
MediHelp also lists interactions of Insulin glargine with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin glargine page.
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