Drug interactions
Cyclopenthiazide + Labetalol
Severity: Minor
Cyclopenthiazide and Labetalol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so the combination is commonly used and the effect is additive. Thiazides can cause hypokalemia, hyperglycemia and hyperuricemia, and beta blockers may mask some signs of hypoglycemia. There is no clinically important adverse interaction beyond additive hypotension.
What this interaction means in plain words
Cyclopenthiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antihypertensive effects through different mechanisms (adrenergic blockade and diuresis).
What to do
Monitor blood pressure and serum potassium and glucose when starting the combination. Adjust doses as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Cyclopenthiazide with Labetalol?
MediHelp rates the interaction as minor. Cyclopenthiazide and Labetalol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs lower blood pressure, so the combination is commonly used and the effect is additive. Thiazides can cause hypokalemia, hyperglycemia and hyperuricemia, and beta blockers may mask some signs of hypoglycemia. There is no clinically important adverse interaction beyond additive hypotension.
How serious is the interaction between Cyclopenthiazide and Labetalol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum potassium and glucose when starting the combination. Adjust doses as needed.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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