Drug interactions
Cyclopenthiazide + Losartan
Severity: Minor
Cyclopenthiazide and Losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics are commonly combined with losartan and the pair has complementary antihypertensive effects. Losartan can offset thiazide-induced potassium loss, but first-dose hypotension and volume depletion-related renal function changes can occur.
What this interaction means in plain words
Cyclopenthiazide and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive blood pressure lowering, with opposing effects on potassium: thiazide-induced kaliuresis versus ARB-mediated reduction in aldosterone-driven potassium excretion.
What to do
Check blood pressure, serum potassium and creatinine after starting or changing doses. Watch for hypotension in volume-depleted patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Frequently asked questions
Can I take Cyclopenthiazide with Losartan?
MediHelp rates the interaction as minor. Cyclopenthiazide and Losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Thiazide diuretics are commonly combined with losartan and the pair has complementary antihypertensive effects. Losartan can offset thiazide-induced potassium loss, but first-dose hypotension and volume depletion-related renal function changes can occur.
How serious is the interaction between Cyclopenthiazide and Losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood pressure, serum potassium and creatinine after starting or changing doses. Watch for hypotension in volume-depleted patients.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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