Drug interactions
Cyclophosphamide + Enalapril-hydrochlorothiazide
Severity: Moderate
Cyclophosphamide and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may enhance the myelosuppressive effect of cyclophosphamide, leading to deeper or more prolonged neutropenia. The interaction is based on limited data.
What this interaction means in plain words
Cyclophosphamide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides may reduce renal clearance of cyclophosphamide or its metabolites, increasing exposure and bone marrow toxicity.
What to do
Monitor complete blood counts, particularly neutrophils, more frequently during chemotherapy cycles. Consider an alternative antihypertensive if marked myelosuppression occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cyclophosphamide and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may enhance the myelosuppressive effect of cyclophosphamide, leading to deeper or more prolonged neutropenia. The interaction is based on limited data.
How serious is the interaction between Cyclophosphamide and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts, particularly neutrophils, more frequently during chemotherapy cycles. Consider an alternative antihypertensive if marked myelosuppression occurs.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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