Drug interactions
Cyclophosphamide + Fosinopril-hydrochlorothiazide
Severity: Moderate
Cyclophosphamide and Fosinopril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics may increase the bone marrow suppression caused by cyclophosphamide, leading to more profound leukopenia. The effect has been described mainly with reduced renal clearance of the cytotoxic metabolites.
What this interaction means in plain words
Cyclophosphamide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Fosinopril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Thiazides appear to reduce renal clearance of cyclophosphamide or its metabolites, increasing myelotoxic exposure.
What to do
Monitor complete blood counts closely, especially neutrophil counts, during cyclophosphamide cycles and consider dose adjustment of cyclophosphamide if marked myelosuppression occurs. Consider an alternative antihypertensive during intensive chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fosinopril-hydrochlorothiazide
- Aliskiren + Fosinopril-hydrochlorothiazide Contraindicated
- Dofetilide + Fosinopril-hydrochlorothiazide Contraindicated
- Fosinopril-hydrochlorothiazide + Protein a column Contraindicated
- Fosinopril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Aldesleukin + Fosinopril-hydrochlorothiazide Major
- Amifostine + Fosinopril-hydrochlorothiazide Major
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Fosinopril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Cyclophosphamide and Fosinopril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics may increase the bone marrow suppression caused by cyclophosphamide, leading to more profound leukopenia. The effect has been described mainly with reduced renal clearance of the cytotoxic metabolites.
How serious is the interaction between Cyclophosphamide and Fosinopril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts closely, especially neutrophil counts, during cyclophosphamide cycles and consider dose adjustment of cyclophosphamide if marked myelosuppression occurs. Consider an alternative antihypertensive during intensive chemotherapy.
What other medicines interact with Fosinopril-hydrochlorothiazide?
MediHelp also lists interactions of Fosinopril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Fosinopril-hydrochlorothiazide page.
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