Drug interactions
Cyclophosphamide + Metaxalone
Severity: Minor
Cyclophosphamide and Metaxalone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclophosphamide is a CYP3A4 substrate and has no well-established inhibitory effect on this enzyme. A clinically meaningful change in metaxalone levels is not expected.
What this interaction means in plain words
Cyclophosphamide and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Metaxalone belongs to Musculoskeletal.
Why it happens
Theoretical CYP3A4 interference that is not established clinically.
What to do
No specific adjustment is needed. Observe for increased drowsiness or dizziness from metaxalone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclophosphamide and Metaxalone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Metaxalone
Other interactions of Cyclophosphamide
Frequently asked questions
Can I take Cyclophosphamide with Metaxalone?
MediHelp rates the interaction as minor. Cyclophosphamide and Metaxalone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cyclophosphamide is a CYP3A4 substrate and has no well-established inhibitory effect on this enzyme. A clinically meaningful change in metaxalone levels is not expected.
How serious is the interaction between Cyclophosphamide and Metaxalone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed. Observe for increased drowsiness or dizziness from metaxalone.
What other medicines interact with Metaxalone?
MediHelp also lists interactions of Metaxalone with, for example, Alfentanil, Belladonna and opium, Benzhydrocodone / acetaminophen. The full list is on the Metaxalone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
