Drug interactions
Cyclophosphamide + Mifepristone
Severity: Moderate
Cyclophosphamide and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone inhibits CYP3A4 and possibly CYP2B6, which could reduce bioactivation of cyclophosphamide and change its metabolite profile. Clinical data are limited and effects on efficacy or toxicity are uncertain.
What this interaction means in plain words
Cyclophosphamide and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Mifepristone belongs to Endocrine.
Why it happens
Predicted CYP3A4/CYP2B6 inhibition by mifepristone altering cyclophosphamide metabolism.
What to do
Monitor treatment response and signs of toxicity such as myelosuppression, and avoid prolonged co-therapy where alternatives exist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Mifepristone?
MediHelp rates the interaction as moderate. Cyclophosphamide and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone inhibits CYP3A4 and possibly CYP2B6, which could reduce bioactivation of cyclophosphamide and change its metabolite profile. Clinical data are limited and effects on efficacy or toxicity are uncertain.
How serious is the interaction between Cyclophosphamide and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and signs of toxicity such as myelosuppression, and avoid prolonged co-therapy where alternatives exist.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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