Drug interactions
Cyclophosphamide + Secobarbital
Severity: Moderate
Cyclophosphamide and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce hepatic enzymes including CYP2B6, which can increase conversion of cyclophosphamide to its active and toxic metabolites. This may increase myelosuppression and other toxicity or alter efficacy.
What this interaction means in plain words
Cyclophosphamide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of CYP2B6 and other CYP enzymes accelerates cyclophosphamide activation.
What to do
Use a non-inducing sedative or anticonvulsant if possible, and monitor blood counts and toxicity if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Secobarbital?
MediHelp rates the interaction as moderate. Cyclophosphamide and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce hepatic enzymes including CYP2B6, which can increase conversion of cyclophosphamide to its active and toxic metabolites. This may increase myelosuppression and other toxicity or alter efficacy.
How serious is the interaction between Cyclophosphamide and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing sedative or anticonvulsant if possible, and monitor blood counts and toxicity if the combination is needed.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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