Drug interactions
Cyclophosphamide + Sparsentan
Severity: Moderate
Cyclophosphamide and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2B6, which helps activate cyclophosphamide. Altered activation could change the balance between therapeutic effect and toxicity, and the clinical effect is not well characterized.
What this interaction means in plain words
Cyclophosphamide and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Sparsentan belongs to Genitourinary.
Why it happens
CYP2B6 induction by sparsentan may alter hepatic activation of cyclophosphamide to its active metabolite.
What to do
Monitor treatment response and toxicity, including blood counts, when the two are used together. Consider alternatives if efficacy appears compromised.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Sparsentan?
MediHelp rates the interaction as moderate. Cyclophosphamide and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP2B6, which helps activate cyclophosphamide. Altered activation could change the balance between therapeutic effect and toxicity, and the clinical effect is not well characterized.
How serious is the interaction between Cyclophosphamide and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor treatment response and toxicity, including blood counts, when the two are used together. Consider alternatives if efficacy appears compromised.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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