Drug interactions
Cyclophosphamide + Verapamil
Severity: Minor
Cyclophosphamide and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and P-glycoprotein, and cyclophosphamide is partly activated by CYP3A4, so verapamil may alter formation of active and toxic metabolites. The clinical effect is uncertain; the legacy direction of effect is not supported.
What this interaction means in plain words
Cyclophosphamide and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Possible CYP3A4 inhibition by verapamil altering cyclophosphamide bioactivation.
What to do
No routine change is needed; monitor for unexpected changes in toxicity or response to cyclophosphamide.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Cyclophosphamide with Verapamil?
MediHelp rates the interaction as minor. Cyclophosphamide and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 and P-glycoprotein, and cyclophosphamide is partly activated by CYP3A4, so verapamil may alter formation of active and toxic metabolites. The clinical effect is uncertain; the legacy direction of effect is not supported.
How serious is the interaction between Cyclophosphamide and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; monitor for unexpected changes in toxicity or response to cyclophosphamide.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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