Drug interactions
Cyclophosphamide + Vinblastine
Severity: Moderate
Cyclophosphamide and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, so combined use can deepen neutropenia and raise infection risk, though they are often combined in standard regimens. The legacy CYP3A4 rationale is not established.
What this interaction means in plain words
Cyclophosphamide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclophosphamide belongs to Oncology; Vinblastine belongs to Oncology.
Why it happens
Additive pharmacodynamic bone marrow suppression.
What to do
Monitor complete blood counts and adjust doses according to neutrophil and platelet nadirs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclophosphamide
Other interactions of Vinblastine
Frequently asked questions
Can I take Cyclophosphamide with Vinblastine?
MediHelp rates the interaction as moderate. Cyclophosphamide and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, so combined use can deepen neutropenia and raise infection risk, though they are often combined in standard regimens. The legacy CYP3A4 rationale is not established.
How serious is the interaction between Cyclophosphamide and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and adjust doses according to neutrophil and platelet nadirs.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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