Drug interactions
Cyclophosphamide + Voclosporin
Severity: Major
Cyclophosphamide and Voclosporin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voclosporin, a calcineurin inhibitor, causes dose-related nephrotoxicity. Cyclophosphamide can injure the urinary tract and is also used in lupus nephritis, where renal function is already compromised. The combination may raise the risk of kidney injury and infection, and labeling advises against use with other strong immunosuppressants such as cyclophosphamide.
What this interaction means in plain words
Cyclophosphamide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclophosphamide belongs to Oncology; Voclosporin belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity and immunosuppression.
What to do
Avoid combining unless the benefit clearly outweighs risk. If used, monitor eGFR, blood pressure, potassium and infection signs closely and reduce the voclosporin dose for renal decline.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclophosphamide
Other interactions of Voclosporin
- Clarithromycin + Voclosporin Contraindicated
- Cyclosporin + Voclosporin Contraindicated
- Ensitrelvir + Voclosporin Contraindicated
- Itraconazole + Voclosporin Contraindicated
- Ketoconazole + Voclosporin Contraindicated
- Posaconazole + Voclosporin Contraindicated
Frequently asked questions
Can I take Cyclophosphamide with Voclosporin?
MediHelp rates the interaction as major. Cyclophosphamide and Voclosporin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Voclosporin, a calcineurin inhibitor, causes dose-related nephrotoxicity. Cyclophosphamide can injure the urinary tract and is also used in lupus nephritis, where renal function is already compromised. The combination may raise the risk of kidney injury and infection, and labeling advises against use with other strong immunosuppressants such as cyclophosphamide.
How serious is the interaction between Cyclophosphamide and Voclosporin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless the benefit clearly outweighs risk. If used, monitor eGFR, blood pressure, potassium and infection signs closely and reduce the voclosporin dose for renal decline.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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