Drug interactions
Cyclophosphamide + Voxelotor
Severity: Minor
Cyclophosphamide and Voxelotor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor increases exposure to sensitive CYP3A4 substrates and may alter cyclophosphamide metabolism. The clinical effect is uncertain because cyclophosphamide is activated mainly by CYP2B6.
What this interaction means in plain words
Cyclophosphamide and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclophosphamide belongs to Oncology; Voxelotor belongs to Miscellaneous.
Why it happens
Weak to moderate CYP3A4 inhibition by voxelotor may alter cyclophosphamide metabolism.
What to do
No routine adjustment is needed. Monitor blood counts and toxicity as usual during cyclophosphamide therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclophosphamide
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Cyclophosphamide with Voxelotor?
MediHelp rates the interaction as minor. Cyclophosphamide and Voxelotor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voxelotor increases exposure to sensitive CYP3A4 substrates and may alter cyclophosphamide metabolism. The clinical effect is uncertain because cyclophosphamide is activated mainly by CYP2B6.
How serious is the interaction between Cyclophosphamide and Voxelotor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor blood counts and toxicity as usual during cyclophosphamide therapy.
What other medicines interact with Cyclophosphamide?
MediHelp also lists interactions of Cyclophosphamide with, for example, Adenovirus types 4 and 7 live, Belatacept, Bendamustine. The full list is on the Cyclophosphamide page.
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