Drug interactions
Cyclosporin + Dexlansoprazole
Severity: Moderate
Cyclosporin and Dexlansoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prolonged proton pump inhibitor use can cause hypomagnesemia, and cyclosporine also causes magnesium wasting. Combined use may increase the risk of low magnesium and related arrhythmia or seizures.
What this interaction means in plain words
Cyclosporin and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Dexlansoprazole belongs to Gastrointestinal Tract.
Why it happens
Additive effects on magnesium handling, with reduced intestinal absorption from PPIs and increased renal loss from cyclosporine.
What to do
Monitor serum magnesium periodically during long-term use and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Dexlansoprazole
- Dexlansoprazole + Mavacamten Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Dexlansoprazole Major
- Atazanavir + Dexlansoprazole Major
- Dacomitinib + Dexlansoprazole Major
- Dasatinib + Dexlansoprazole Major
Frequently asked questions
Can I take Cyclosporin with Dexlansoprazole?
MediHelp rates the interaction as moderate. Cyclosporin and Dexlansoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Prolonged proton pump inhibitor use can cause hypomagnesemia, and cyclosporine also causes magnesium wasting. Combined use may increase the risk of low magnesium and related arrhythmia or seizures.
How serious is the interaction between Cyclosporin and Dexlansoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium periodically during long-term use and replace as needed.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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