Drug interactions
Cyclosporin + Diclofenac
Severity: Major
Cyclosporin and Diclofenac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Diclofenac can reduce renal blood flow and worsen cyclosporine nephrotoxicity. Cyclosporine may also raise diclofenac exposure, which can increase the risk of renal impairment.
What this interaction means in plain words
Cyclosporin and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Diclofenac belongs to Musculoskeletal.
Why it happens
Additive renal vasoconstriction from prostaglandin inhibition and calcineurin inhibition, with possible pharmacokinetic increase in diclofenac levels.
What to do
Avoid if possible; if used, give the lowest effective diclofenac dose (labeling suggests a reduced dose) and monitor serum creatinine and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Diclofenac, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Frequently asked questions
Can I take Cyclosporin with Diclofenac?
MediHelp rates the interaction as major. Cyclosporin and Diclofenac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Diclofenac can reduce renal blood flow and worsen cyclosporine nephrotoxicity. Cyclosporine may also raise diclofenac exposure, which can increase the risk of renal impairment.
How serious is the interaction between Cyclosporin and Diclofenac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; if used, give the lowest effective diclofenac dose (labeling suggests a reduced dose) and monitor serum creatinine and blood pressure.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
