Drug interactions
Cyclosporin + Duvelisib
Severity: Major
Cyclosporin and Duvelisib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and can raise cyclosporine levels, increasing toxicity. Cyclosporine may also increase duvelisib exposure via P-gp and BCRP inhibition and add to immunosuppression and infection risk.
What this interaction means in plain words
Cyclosporin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4 affecting cyclosporine, while cyclosporine inhibits P-gp, BCRP and CYP3A4 affecting duvelisib.
What to do
Monitor cyclosporine trough levels and renal function, and reduce its dose as needed. Watch for duvelisib toxicity such as infections, diarrhea and skin reactions.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Cyclosporin with Duvelisib?
MediHelp rates the interaction as major. Cyclosporin and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and can raise cyclosporine levels, increasing toxicity. Cyclosporine may also increase duvelisib exposure via P-gp and BCRP inhibition and add to immunosuppression and infection risk.
How serious is the interaction between Cyclosporin and Duvelisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and reduce its dose as needed. Watch for duvelisib toxicity such as infections, diarrhea and skin reactions.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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