Drug interactions
Cyclosporin + Elacestrant
Severity: Moderate
Cyclosporin and Elacestrant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may raise elacestrant exposure via CYP3A4 inhibition, increasing adverse effects such as nausea, dyslipidemia and musculoskeletal pain.
What this interaction means in plain words
Cyclosporin and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Elacestrant belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated elacestrant metabolism and possibly P-gp efflux.
What to do
Avoid combining with strong CYP3A4 inhibitors; with cyclosporine, monitor for elacestrant adverse effects and consider an alternative immunosuppressant if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Elacestrant
Frequently asked questions
Can I take Cyclosporin with Elacestrant?
MediHelp rates the interaction as moderate. Cyclosporin and Elacestrant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may raise elacestrant exposure via CYP3A4 inhibition, increasing adverse effects such as nausea, dyslipidemia and musculoskeletal pain.
How serious is the interaction between Cyclosporin and Elacestrant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining with strong CYP3A4 inhibitors; with cyclosporine, monitor for elacestrant adverse effects and consider an alternative immunosuppressant if toxicity occurs.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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