Drug interactions
Cyclosporin + Etodolac
Severity: Major
Cyclosporin and Etodolac: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etodolac can reduce renal prostaglandin synthesis and add to cyclosporine nephrotoxicity. This may cause reduced glomerular filtration, fluid retention and hypertension.
What this interaction means in plain words
Cyclosporin and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Etodolac belongs to Musculoskeletal.
Why it happens
Additive renal vasoconstriction from NSAID prostaglandin inhibition and calcineurin inhibition.
What to do
Avoid concurrent use where possible; otherwise monitor serum creatinine and blood pressure and stop the NSAID if renal function worsens.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Etodolac
- Etodolac + Ketorolac Contraindicated
- Etodolac + Ketorolac intranasal Contraindicated
- Aceclofenac + Etodolac Major
- Acemetacin + Etodolac Major
- Acetylsalicylic acid + Etodolac Major
- Alteplase + Etodolac Major
Frequently asked questions
Can I take Cyclosporin with Etodolac?
MediHelp rates the interaction as major. Cyclosporin and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etodolac can reduce renal prostaglandin synthesis and add to cyclosporine nephrotoxicity. This may cause reduced glomerular filtration, fluid retention and hypertension.
How serious is the interaction between Cyclosporin and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible; otherwise monitor serum creatinine and blood pressure and stop the NSAID if renal function worsens.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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