Drug interactions
Cyclosporin + Famotidine
Severity: Minor
Cyclosporin and Famotidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Famotidine has been reported to delay cyclosporin absorption, but clinically significant changes in exposure are uncommon. The effect is generally small.
What this interaction means in plain words
Cyclosporin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Famotidine belongs to Gastrointestinal Tract.
Why it happens
Possible change in gastric pH or absorption kinetics; the mechanism is not firmly established.
What to do
No routine adjustment is needed; check cyclosporin trough levels if graft function or toxicity signs change after famotidine is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Famotidine
Frequently asked questions
Can I take Cyclosporin with Famotidine?
MediHelp rates the interaction as minor. Cyclosporin and Famotidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Famotidine has been reported to delay cyclosporin absorption, but clinically significant changes in exposure are uncommon. The effect is generally small.
How serious is the interaction between Cyclosporin and Famotidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; check cyclosporin trough levels if graft function or toxicity signs change after famotidine is started.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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