Drug interactions
Cyclosporin + Felodipine
Severity: Moderate
Cyclosporin and Felodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporin can raise felodipine concentrations, causing hypotension, edema and flushing. Felodipine may also modestly raise cyclosporin levels and gingival hyperplasia risk.
What this interaction means in plain words
Cyclosporin and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Felodipine belongs to Cardiovascular.
Why it happens
Cyclosporin inhibits CYP3A4 metabolism of felodipine, with possible reciprocal P-glycoprotein effects.
What to do
Start felodipine at a low dose and titrate to blood pressure, and monitor cyclosporin levels and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cyclosporin and Felodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Felodipine
- Felodipine + Itraconazole Contraindicated
- Aldesleukin + Felodipine Major
- Amifostine + Felodipine Major
- Apalutamide + Felodipine Major
- Atazanavir + Felodipine Major
- Carbamazepine + Felodipine Major
Frequently asked questions
Can I take Cyclosporin with Felodipine?
MediHelp rates the interaction as moderate. Cyclosporin and Felodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporin can raise felodipine concentrations, causing hypotension, edema and flushing. Felodipine may also modestly raise cyclosporin levels and gingival hyperplasia risk.
How serious is the interaction between Cyclosporin and Felodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start felodipine at a low dose and titrate to blood pressure, and monitor cyclosporin levels and renal function.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
