Drug interactions
Cyclosporin + Guanfacine
Severity: Moderate
Cyclosporin and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may substantially increase guanfacine exposure by inhibiting CYP3A4. This may result in hypotension, bradycardia and sedation.
What this interaction means in plain words
Cyclosporin and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Guanfacine belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4-mediated guanfacine metabolism by cyclosporine.
What to do
Halve the guanfacine extended-release dose during co-administration and monitor blood pressure, heart rate and sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
Frequently asked questions
Can I take Cyclosporin with Guanfacine?
MediHelp rates the interaction as moderate. Cyclosporin and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine may substantially increase guanfacine exposure by inhibiting CYP3A4. This may result in hypotension, bradycardia and sedation.
How serious is the interaction between Cyclosporin and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Halve the guanfacine extended-release dose during co-administration and monitor blood pressure, heart rate and sedation.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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