Drug interactions
Amisulpride + Guanfacine
Severity: Moderate
Amisulpride and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Guanfacine causes somnolence, and amisulpride can add to the sedative effect. Both may also lower blood pressure or heart rate, which may add to dizziness.
What this interaction means in plain words
Amisulpride and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amisulpride belongs to Central Nervous System; Guanfacine belongs to Cardiovascular.
Why it happens
Additive CNS depression and hypotension from alpha-2 agonism and dopamine D2/alpha-adrenergic effects.
What to do
Monitor sedation, blood pressure and heart rate, particularly after dose changes. Titrate guanfacine slowly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amisulpride
- Amiodarone + Amisulpride Contraindicated
- Amisulpride + Arsenic trioxide Contraindicated
- Amisulpride + Disopyramide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amisulpride + Droperidol Contraindicated
- Amisulpride + Ibutilide Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amiodarone + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
- Amobarbital + Guanfacine Moderate
Frequently asked questions
Can I take Amisulpride with Guanfacine?
MediHelp rates the interaction as moderate. Amisulpride and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Guanfacine causes somnolence, and amisulpride can add to the sedative effect. Both may also lower blood pressure or heart rate, which may add to dizziness.
How serious is the interaction between Amisulpride and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, blood pressure and heart rate, particularly after dose changes. Titrate guanfacine slowly.
What other medicines interact with Amisulpride?
MediHelp also lists interactions of Amisulpride with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Amisulpride page.
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