Drug interactions
Amiodarone + Guanfacine
Severity: Moderate
Amiodarone and Guanfacine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amiodarone may increase guanfacine concentrations, and both agents can slow the heart rate and lower blood pressure. This increases the risk of bradycardia, hypotension and sedation.
What this interaction means in plain words
Amiodarone and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amiodarone belongs to Cardiovascular; Guanfacine belongs to Cardiovascular.
Why it happens
CYP3A4 inhibition by amiodarone raising guanfacine levels, with additive bradycardic and hypotensive effects.
What to do
Reduce extended-release guanfacine to half the usual dose as labeled and monitor heart rate and blood pressure. Titrate on tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amiodarone
- Amiodarone + Amisulpride Contraindicated
- Amiodarone + Arsenic trioxide Contraindicated
- Amiodarone + Dofetilide Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Amiodarone + Droperidol Contraindicated
- Amiodarone + Eliglustat Contraindicated
Other interactions of Guanfacine
- Clonidine + Guanfacine Major
- Guanfacine + Lofexidine Major
- Aldesleukin + Guanfacine Moderate
- Amisulpride + Guanfacine Moderate
- Amitriptyline + Guanfacine Moderate
- Amobarbital + Guanfacine Moderate
Frequently asked questions
Can I take Amiodarone with Guanfacine?
MediHelp rates the interaction as moderate. Amiodarone and Guanfacine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amiodarone may increase guanfacine concentrations, and both agents can slow the heart rate and lower blood pressure. This increases the risk of bradycardia, hypotension and sedation.
How serious is the interaction between Amiodarone and Guanfacine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce extended-release guanfacine to half the usual dose as labeled and monitor heart rate and blood pressure. Titrate on tolerability.
What other medicines interact with Amiodarone?
MediHelp also lists interactions of Amiodarone with, for example, Amisulpride, Arsenic trioxide, Dofetilide. The full list is on the Amiodarone page.
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