Drug interactions
Cyclosporin + Guselkumab
Severity: Minor
Cyclosporin and Guselkumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 enzyme expression, and effective IL-23 blockade may restore it, theoretically lowering cyclosporine concentrations. No meaningful interaction has been established and the effect is expected to be small. Additive immunosuppression also warrants attention.
What this interaction means in plain words
Cyclosporin and Guselkumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cyclosporin belongs to Miscellaneous; Guselkumab belongs to Miscellaneous.
Why it happens
Normalization of cytokine-suppressed CYP450 activity may modestly increase cyclosporine clearance; this is theoretical.
What to do
Monitor cyclosporine trough levels and clinical response when guselkumab is started or stopped. Monitor for infection given combined immunosuppression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Cyclosporin with Guselkumab?
MediHelp rates the interaction as minor. Cyclosporin and Guselkumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 enzyme expression, and effective IL-23 blockade may restore it, theoretically lowering cyclosporine concentrations. No meaningful interaction has been established and the effect is expected to be small. Additive immunosuppression also warrants attention.
How serious is the interaction between Cyclosporin and Guselkumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and clinical response when guselkumab is started or stopped. Monitor for infection given combined immunosuppression.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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