Drug interactions
Cyclosporin + Isavuconazonium
Severity: Moderate
Cyclosporin and Isavuconazonium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isavuconazole, the active moiety of isavuconazonium, inhibits CYP3A4 and P-glycoprotein and can raise cyclosporine exposure, increasing the risk of nephrotoxicity, hypertension and neurotoxicity. Cyclosporine may modestly affect isavuconazole levels, and both agents contribute to immunosuppression and infection risk.
What this interaction means in plain words
Cyclosporin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Isavuconazonium belongs to Anti Fungals.
Why it happens
Isavuconazole inhibits CYP3A4 and P-glycoprotein, reducing cyclosporine clearance.
What to do
Measure cyclosporine trough concentrations when starting or stopping isavuconazonium and reduce the cyclosporine dose as needed. Monitor renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Isavuconazonium
- Amobarbital + Isavuconazonium Contraindicated
- Apalutamide + Isavuconazonium Contraindicated
- Carbamazepine + Isavuconazonium Contraindicated
- Cisapride + Isavuconazonium Contraindicated
- Efavirenz + Isavuconazonium Contraindicated
- Enzalutamide + Isavuconazonium Contraindicated
Frequently asked questions
Can I take Cyclosporin with Isavuconazonium?
MediHelp rates the interaction as moderate. Cyclosporin and Isavuconazonium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Isavuconazole, the active moiety of isavuconazonium, inhibits CYP3A4 and P-glycoprotein and can raise cyclosporine exposure, increasing the risk of nephrotoxicity, hypertension and neurotoxicity. Cyclosporine may modestly affect isavuconazole levels, and both agents contribute to immunosuppression and infection risk.
How serious is the interaction between Cyclosporin and Isavuconazonium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure cyclosporine trough concentrations when starting or stopping isavuconazonium and reduce the cyclosporine dose as needed. Monitor renal function and blood pressure.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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