Drug interactions
Cyclosporin + Lapatinib
Severity: Major
Cyclosporin and Lapatinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs inhibit CYP3A4 and P-glycoprotein and are substrates of them, so concentrations of each may rise. This can increase cyclosporine toxicity and lapatinib adverse effects such as QT prolongation, hepatotoxicity and diarrhea.
What this interaction means in plain words
Cyclosporin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Mutual inhibition of CYP3A4 and P-glycoprotein reduces clearance of both drugs.
What to do
Monitor cyclosporine trough levels and renal function, and consider an ECG and liver tests. Reduce doses if toxicity appears or consider alternatives.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Frequently asked questions
Can I take Cyclosporin with Lapatinib?
MediHelp rates the interaction as major. Cyclosporin and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs inhibit CYP3A4 and P-glycoprotein and are substrates of them, so concentrations of each may rise. This can increase cyclosporine toxicity and lapatinib adverse effects such as QT prolongation, hepatotoxicity and diarrhea.
How serious is the interaction between Cyclosporin and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function, and consider an ECG and liver tests. Reduce doses if toxicity appears or consider alternatives.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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