Drug interactions
Cyclosporin + Lemborexant
Severity: Major
Cyclosporin and Lemborexant: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine may increase lemborexant levels via CYP3A4 inhibition. This may cause excessive somnolence and next-day impairment.
What this interaction means in plain words
Cyclosporin and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Lemborexant belongs to Central Nervous System.
Why it happens
Cyclosporine inhibits CYP3A4, reducing lemborexant clearance.
What to do
Avoid coadministration with moderate CYP3A inhibitors per labeling, or use a non-interacting hypnotic. Monitor for daytime sedation if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lemborexant
Frequently asked questions
Can I take Cyclosporin with Lemborexant?
MediHelp rates the interaction as major. Cyclosporin and Lemborexant can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine may increase lemborexant levels via CYP3A4 inhibition. This may cause excessive somnolence and next-day impairment.
How serious is the interaction between Cyclosporin and Lemborexant?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration with moderate CYP3A inhibitors per labeling, or use a non-interacting hypnotic. Monitor for daytime sedation if unavoidable.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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