Drug interactions
Cyclosporin + Linvoseltamab
Severity: Moderate
Cyclosporin and Linvoseltamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linvoseltamab causes transient cytokine release that can suppress CYP450 enzyme activity. Cyclosporine levels may therefore rise temporarily, mainly around step-up doses and the first full dose.
What this interaction means in plain words
Cyclosporin and Linvoseltamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Linvoseltamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP450 enzymes reduces cyclosporine metabolism.
What to do
Monitor cyclosporine concentrations and signs of toxicity during the step-up period and after the first full dose, adjusting dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linvoseltamab
- Linvoseltamab + Phenytoin Moderate
- Linvoseltamab + Sirolimus Moderate
- Linvoseltamab + Warfarin Moderate
Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Frequently asked questions
Can I take Cyclosporin with Linvoseltamab?
MediHelp rates the interaction as moderate. Cyclosporin and Linvoseltamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linvoseltamab causes transient cytokine release that can suppress CYP450 enzyme activity. Cyclosporine levels may therefore rise temporarily, mainly around step-up doses and the first full dose.
How serious is the interaction between Cyclosporin and Linvoseltamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine concentrations and signs of toxicity during the step-up period and after the first full dose, adjusting dose as needed.
What other medicines interact with Linvoseltamab?
MediHelp also lists interactions of Linvoseltamab with, for example, Phenytoin, Sirolimus, Warfarin. The full list is on the Linvoseltamab page.
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