Drug interactions
Linvoseltamab + Warfarin
Severity: Moderate
Linvoseltamab and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release after linvoseltamab may transiently suppress CYP enzymes that metabolize warfarin, increasing its anticoagulant effect. This raises the risk of bleeding.
What this interaction means in plain words
Linvoseltamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linvoseltamab belongs to Oncology; Warfarin belongs to Cardiovascular.
Why it happens
Cytokine-mediated suppression of CYP2C9 and other CYPs reduces warfarin clearance.
What to do
Monitor INR more frequently during step-up dosing and after the first full dose, adjusting warfarin as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linvoseltamab
- Cyclosporin + Linvoseltamab Moderate
- Linvoseltamab + Phenytoin Moderate
- Linvoseltamab + Sirolimus Moderate
Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Frequently asked questions
Can I take Linvoseltamab with Warfarin?
MediHelp rates the interaction as moderate. Linvoseltamab and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release after linvoseltamab may transiently suppress CYP enzymes that metabolize warfarin, increasing its anticoagulant effect. This raises the risk of bleeding.
How serious is the interaction between Linvoseltamab and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor INR more frequently during step-up dosing and after the first full dose, adjusting warfarin as needed.
What other medicines interact with Linvoseltamab?
MediHelp also lists interactions of Linvoseltamab with, for example, Cyclosporin, Phenytoin, Sirolimus. The full list is on the Linvoseltamab page.
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