Drug interactions
Linvoseltamab + Sirolimus
Severity: Moderate
Linvoseltamab and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine elevation following linvoseltamab can transiently inhibit CYP3A4 and raise sirolimus concentrations. Higher levels may cause myelosuppression, hyperlipidemia and impaired wound healing.
What this interaction means in plain words
Linvoseltamab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Linvoseltamab belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces sirolimus clearance.
What to do
Monitor sirolimus trough levels during step-up dosing and after the first full dose, and adjust the dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Linvoseltamab
- Cyclosporin + Linvoseltamab Moderate
- Linvoseltamab + Phenytoin Moderate
- Linvoseltamab + Warfarin Moderate
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Linvoseltamab with Sirolimus?
MediHelp rates the interaction as moderate. Linvoseltamab and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine elevation following linvoseltamab can transiently inhibit CYP3A4 and raise sirolimus concentrations. Higher levels may cause myelosuppression, hyperlipidemia and impaired wound healing.
How serious is the interaction between Linvoseltamab and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough levels during step-up dosing and after the first full dose, and adjust the dose accordingly.
What other medicines interact with Linvoseltamab?
MediHelp also lists interactions of Linvoseltamab with, for example, Cyclosporin, Phenytoin, Warfarin. The full list is on the Linvoseltamab page.
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