Drug interactions
Cyclosporin + Lurbinectedin
Severity: Major
Cyclosporin and Lurbinectedin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits CYP3A4 and may increase lurbinectedin exposure. This could increase myelosuppression, hepatotoxicity and other adverse effects.
What this interaction means in plain words
Cyclosporin and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cyclosporin belongs to Miscellaneous; Lurbinectedin belongs to Oncology.
Why it happens
Inhibition of CYP3A4-mediated lurbinectedin metabolism by cyclosporine.
What to do
Prefer an alternative immunosuppressant or avoid the combination. If it cannot be avoided, consider a lurbinectedin dose reduction per labeling and monitor blood counts and liver enzymes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Lurbinectedin
Frequently asked questions
Can I take Cyclosporin with Lurbinectedin?
MediHelp rates the interaction as major. Cyclosporin and Lurbinectedin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cyclosporine inhibits CYP3A4 and may increase lurbinectedin exposure. This could increase myelosuppression, hepatotoxicity and other adverse effects.
How serious is the interaction between Cyclosporin and Lurbinectedin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative immunosuppressant or avoid the combination. If it cannot be avoided, consider a lurbinectedin dose reduction per labeling and monitor blood counts and liver enzymes.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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