Drug interactions
Cyclosporin + Naldemedine
Severity: Moderate
Cyclosporin and Naldemedine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyclosporine inhibits P-gp and CYP3A4 and may raise naldemedine concentrations, which could increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Cyclosporin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Cyclosporine inhibits CYP3A4 and P-glycoprotein, reducing naldemedine clearance and efflux.
What to do
Monitor for naldemedine adverse effects such as abdominal pain and diarrhea, and stop it if they are severe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Cyclosporin with Naldemedine?
MediHelp rates the interaction as moderate. Cyclosporin and Naldemedine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyclosporine inhibits P-gp and CYP3A4 and may raise naldemedine concentrations, which could increase gastrointestinal adverse effects such as abdominal pain and diarrhea.
How serious is the interaction between Cyclosporin and Naldemedine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for naldemedine adverse effects such as abdominal pain and diarrhea, and stop it if they are severe.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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